Akane Nishino/Relationships

Unnamed Parents
Akane's mother and father deeply loved and cared for her. After she was kidnapped during middle school, her parents had a driver wait for her to safely get between school and home. Her parents cared for her enough to ensure she wasn't involved in another scandal after Minoru saved her by not going public with the case. They were also worried her going to school the day after her second kidnapping.

Akira Nishino
Akane's older brother; despite being siblings, there was no familial affection between them. Akane was fully aware that Akira was using her and her status as a "Knight" to advance his political agenda. He even went as far as to experiment on her by injecting her with blood from multiple Beasts, turning her into the "First Knight", though she initially had no memory of what he had done to her.

Yuuka
Messiah's nurse; Akane was betrayed by Yuuka who revealed herself as a Arcadia survivor and sought revenge on the "First Knight". She did this by causing her go berserk injecting Mordred's blood in her, regaining her memories in the process. She would end up being happily killed by the rampaging Akane as she was able to make her suffer with the recollections of her crimes. Unfortunately for her, the Knight was almost immediately incapacitated and healed by Minoru. This allowed her to instead come to terms with her past than be sunken by it.

Haitani
The commander of Messiah's "Knights" and thus Akane's superior; Haitani seems to be one of the few people who Akane genuinely respect.

Minoru Kagenō / The "Black Knight"
Initially, Akane despised Minoru. Not because he wouldn't remember her name but because he, as she put it, "never looked at her"; he technically turned his eyes at her but was looking past her and setting sights on some far-off place. She actively tried her best to avoid him and kept their conversations brief.

Upon her second kidnapping, a ski-masked vigilante rescued her. Before he left, the vigilante told Akane to be careful and not to get kidnapped. After the incident, Minoru finally paid attention to her and remembered her name. Akane realized that like her, Minoru was also masking his true self and figured out that he was the vigilante and developed romantic feelings for him. Minoru's death deeply affected her to the point she kept his school uniform, yearning for him to return to her even years later.

The two would meet again in his next life in an abandoned hospital when Cid and Beta traveled to Earth. After being found and taken to the Messiah, Cid used his name from his previous life. She was taken aback and noted the resemblance between the two. Sometime after, she decided to take him under care out of suspicion of that the resemblance has a correlation. She came to his defense when Yuudai Saejima suspected him as a spy. After the death of Yuudai, Minoru in return come to her defense and investigate the incident. After the stampede, he found Yuuka who revealed her to be the "First Knight".

After being forced into her First Knight state, she was returned to normal by the Black Knight who told Akane the same lines Minoru said to her when he rescued her. After being brought to another world by Beta. Akane realized that the Black Knight was Minoru. Yearning to reunite with him, she vowed to atone for her past sins, and wished him to wait for her.

Yuudai Saejima
The vice-commander of Messiah's "Knights" and Akane's former classmate; Yudai constantly tried to coerce Akane into a relationship with him and was even willing to blackmail her with knowledge about her past. Akane, on the other hand, not only had no respect for her superior but was utterly repulsed by him. The two also argued on other issues, such as being critical of her for bringing more people into the already overcrowded Messiah and taking Minoru under her care.

Natsume
Akane assumed 'Natsume' to be an "Awakened" person due to her silver hair and long ears. She was against her brother taking custody of her, subconsciously realizing that he would experiment on her as he did on herself, but was overruled, leaving her to pray for her safety. Akane is later brought to the other world by Natsume under her care by Alpha's order after fearing that Eta would do multiple experiments on an alien like her.