Akane Nishino/Relationships

Unnamed Parents
Akane's mother and father deeply loved and cared for her. After she was kidnapped during middle school, her parents had a driver wait for her to safely get between school and home. Her parents cared for her enough to ensure she wasn't involved in another scandal after Minoru saved her by not going public with the case. They were also worried of her going to school the day after her second kidnapping.

Akira Nishino
Akane's older brother; despite being siblings, there was no familial affection between them. She was fully aware that he used her and her status as a "Knight" to advance his political agenda. He even went as far as to experiment on her by injecting her with blood from multiple Beasts, turning her into the "First Knight", though she initially had no memory of what he had done to her.

Yuuka
Nurse for the Messiah; Akane was betrayed by Yuuka after she revealed herself as a survivor of Arcadia and sought revenge on the "First Knight". She did this by causing her go berserk via injecting Brute's blood in her, regaining her memories in the process. She would end up being happily killed by the rampaging Akane as she was able to make her suffer with the recollections of her crimes. Unfortunately for her, the First Knight was instantaneously incapacitated and healed by Minoru. This allowed her to instead come to terms with her past than be sunken by it after being brought to the Other World by Beta.

Haitani
The Knight commander of Messiah and thus Akane's superior; Haitani seems to be one of the few people who Akane genuinely respect.

Minoru Kagenō / The "Black Knight"
Initially, Akane despised Minoru. Not because he wouldn't remember her name but because he, as she put it, "never looked at her"; he technically turned his eyes at her but was looking past her and setting sights on some far-off place. She actively tried her best to avoid him and kept their conversations brief.

Upon her second kidnapping, a ski-masked vigilante rescued her. Before he left, the vigilante told Akane to be careful and not to get kidnapped. After the incident, Minoru finally paid attention to her and remembered her name. Akane realized that like her, Minoru was also masking his true self and figured out that he was the vigilante and developed romantic feelings for him. But their relationship didn't have any further progression, due to his death. Minoru's death deeply affected her to the point she kept his school uniform, yearning for him to return to her even years later.

The two would meet again in his next life in an abandoned hospital when Cid and Beta traveled to Earth. After being found and taken to the Messiah, Cid used his name from his previous life when asked by Yuuka. She was taken aback and noted the resemblance between the two. Sometime after, she decided to take him under care out of suspicion of that the resemblance had a correlation. She defended him when Yuudai Saejima suspected him as a spy. After the death of her former classmate, Minoru in return came to her defense and investigated the incident. After the stampede, he confronted the nurse who revealed herself and the former student as the perpetrator and First Knight respectively.

After being forced into her First Knight state, she was returned to normal by the Black Knight who told Akane the same lines Minoru said to her when he rescued her. After being brought to the Other World by Beta, when she woke up she'd realized that the Black Knight was Minoru, glad to know that he was still alive and hasn't changed, she yearns to reunite with him. Wanting to come to terms with her past, she vowed to atone for them before she can reunite with him once more.

Yuudai Saejima
The vice-commander of Messiah's "Knights" and Akane's former classmate; Yuudai repeatedly tried to coerce her into a relationship with him and was even willing to blackmail her with knowledge of her past. Akane, on the other hand, not only held no respect for her superior but was utterly repulsed by him. The two also argued on various issues, such as him being critical of her for bringing more people into the already overcrowded Messiah and taking Minoru under her care.

In a jealous rage and attempt at scapegoating, the former student confronted Minoru and accused him of being a spy before attempting to have him eaten by magical beasts. Enraged, Akane furiously stopped Yuudai from escalating the situation and defended Minoru. Due to her poor relation with her former classmate, she was accused of murdering him after he was found dead in the aftermath of a stampede. Unbeknownst to her and the Messiah, Yuudai was an agent for the Alliance who was supported the actual spy.

Natsume
Akane assumed 'Natsume' was an "Awakened" like her due to her silver hair and long ears. She was against her brother taking custody of her, subconsciously realizing that he would experiment on her as he did on herself. Despite her protests, she was ultimately overruled and was forced to pray for her safety. She was later brought to the other world by the Elven under her care by Alpha's order after she dreaded of the things Eta would do her in her dozens of experiments on an alien like her.