Akane Nishino/Relationships

Akira Nishino
Akane's older brother; despite being siblings, there was no familial affection between them. Akane was fully aware that Akira was using her and her status as a "Knight" to advance his political agenda. He even went as far as to experiment on her by injecting her with blood from multiple Beasts, turning her into the "First Knight", though she initially had no memory of what he had done to her.

Yuuka
Messiah's nurse; Akane was betrayed by Yuka, who was an Arcadia survivor and wanted revenge on the "First Knight". She would do this by making her go berserk by injecting her with Mordred's blood, regaining her memories in the process. Yuka would end up being killed by the rampaging Akane but did not care as she was able to make her suffer with the knowledge of her crimes. Unfortunately for Yuka, Akane was almost immediately incapacitated and healed by Cid, allowing her to instead come to terms with her past.

Haitani
The commander of Messiah's "Knights" and thus Akane's superior; Haitani seems to be one of the few people who Akane genuinely respects.

Minoru Kagenō / The "Black Knight"
At the start, Akane despised Minoru, not because he did not remember her name but because he, as she put it, "never looked at her"; he technically turned his eyes at her but was looking past her and setting sights on some far-off place. She tried her best to avoid him at all times and kept their conversations incredibly short.

When Akane got kidnapped, a ski-masked vigilante rescued her. Before he left, the vigilante told Akane to be careful and not to get kidnapped. After that, when Minoru finally paid attention to her and remembered her name, Akane realized that like her, Minoru was also masking his true self. Eventually, Akane figured out that Minoru was the vigilante and she developed romantic feelings for him. Minoru's death deeply affected her, keeping his school uniform and yearning for him to return to her even years later.

After being forced into her First Knight state, she was returned to normal by the Black Knight who told Akane the same lines Minoru said to her when he rescued her. Akane realized that the Black Knight was Minoru.

Yuudai Saejima
The vice-commander of Messiah's "Knights" and Akane's former high school classmate; Yudai constantly tried to force Akane into a relationship with him, even willing to blackmail her with knowledge about her past. Akane, on the other hand, not only had no respect for her superior but was utterly repulsed by him. The two also disagreed on other issues, with Yudai being critical of Akane bringing more people into the already overcrowded Messiah.

Natsume
Akane assumed 'Natsume' to be an "Awakened" person due to her silver hair and long ears. She was against her brother taking custody of her, subconsciously realizing that he would experiment on her as he did on herself, but was overruled, leaving her to pray for her safety. Akane is later brought to the other world by Natsume under her care by Alpha's order after fearing that Eta would do multiple experiments on an alien like her.